ADC linkers
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Description
Mass spectrometry techniques can be used to evaluate the stability of the linker, analyze free drugs, metabolites, different DAR components, and relative proportions. LC/MS, such as HIC or RP-HPLC coupled...
show moreOne of the challenges of mass spectrometry technology is that all substances have the same ionization efficiency as unconjugated antibodies, regardless of drug loading. Therefore, the premise of applying spectroscopy to the analysis of DAR conjugation is to assume that all materials have the same recovery and ionization. This is not always the case, as the coupling of the drug to the positively charged amine will result in a change in the charge and degree of hydrophobicity.
https://www.creative-biolabs.com/adc/classify-adc-linkers-7.htm
Information
Author | Bella Smith |
Organization | Bella Smith |
Website | - |
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