Welcome to this inspiring episode of MS health and wellness, where we delve into the evidence-based impact of smoking and alcohol consumption in MS. Our special guest is Associate Professor Rod Middleton, who brings extensive experience and expertise in health informatics, data linkage, and direct healthcare provision. Rod is the Principal Investigator and System Architect of the UK MS Register, and we are thrilled to have him on the show.With over 110,000 diagnosed cases of MS in the UK, and around 5,000 new diagnoses each year, understanding the impact of lifestyle factors such as smoking and alcohol consumption is crucial. Recent studies show that smoking is a risk factor for developing MS, and that rates of smoking are higher among people with MS than in the general population. In fact, some studies suggest that smoking can increase the risk of developing MS by up to 50%.In this episode, we delve into the insights that the UK MS Register has provided on the lifestyle patterns of people living with MS. We explore the current evidence on smoking and its impact on MS disease activity and progression. We also examine the current evidence on excessive alcohol consumption and its effects on MS, and whether moderate alcohol consumption is still advisable for people with MS.Moreover, we discuss the combined impact of alcohol and smoking on MS, and whether there is any evidence-based research exploring the impact of this combination. As we learn from Associate Professor Rod Middleton's extensive knowledge and expertise, we explore the practical aspects of MS management through lifestyle choices.So, stay tuned and watch this space for an inspiring and insightful discussion that highlights the importance of making informed lifestyle choices when living with MS.