Brian De Palma, a celebrated filmmaker known for masterpieces like "Scarface," "Carrie," and "The Untouchables," experienced significant setbacks with his sci-fi adventure film "Mission to Mars" in 2000. This film diverged from De Palma's usual genre, venturing into a realm deeply inspired by classic space exploration narratives. "Mission to Mars," though based on an original story, incorporated thematic elements that drew from both real scientific pursuits and beloved science fiction tropes.

Despite the eye-catching visual effects and ambitious storyline, "Mission to Mars" was met with critical disdain. Critics lambasted the film for its implausible plot and lackluster script, which overshadowed the more positively received aspects like its innovative special effects and the performances of a star-studded cast including Gary Sinise, Tim Robbins, and Don Cheadle. These elements, usually benchmarks of successful science fiction, failed to salvage the film's reputation or box office returns.

The film's poor reception presented a harsh blow to De Palma, who had by then established a reputation for gripping thrillers and intense dramas. The critical failure of "Mission to Mars" undeniably impacted his career trajectory, shifting the momentum he had built up over decades. It forced a reevaluation of his directorial choices, pushing him to return to genres where he held a proven track record.

This experience showcased the precarious nature of genre experimentation in Hollywood, particularly when diverging from a filmmaker’s established strengths. It also highlighted the unpredictable nature of audience and critical reception, serving as a case study in how even veterans like De Palma are not immune to the ups and downs of filmmaking. Despite this setback, De Palma's influence on the thriller and crime genres remains undisputed, illustrating his resilience and enduring legacy in the film industry.