In the development of Antibody-drug conjugates (ADCs), the design of suitable linkers is crucial for the stable and efficient delivery of the cytotoxic drug to the target cells. An ideal linker should possess exceeding stability in systemic circulation, and readily releases the cytotoxic payload in its active form upon reaching the target site. Linker design for ADCs is highly dependent on the biolology of the target cells, the characteristics of the antibody, and the structure of the drug molecule. Selection of the optimal linker is achieved through efficacy and toxicity assessments for each individual ADC construct. https://www.creative-biolabs.com/adc/linker-module.htm