Presented by Diane M. Birnbaumer, MD, FACEP   To earn ACCME or ACPE credit, go online to scientiacme.org/cmecoursecontent.php?ID=278 to view the slides and complete the post-test.   In this online CME self-learning program: Influenza has been recognized as a global public health menace since at least 100 years ago with the 1918-19 pandemic, which infected an estimated one-third of the world’s population and was responsible for the deaths of one in ten, or 50 million, of those infected. While some have contended that a significant number of deaths associated with the 1918 pandemic may have actually been attributable to acid-base derangements and pulmonary edema associated with contemporary aspirin dosing in the toxic range of two to eight times what is presently the maximum recommended dose – it remains a significant public health concern, with the 2017-2018 flu season in recent decades with an estimated 80,000 deaths (typical range 12,000-56,000 per year),coming with an annual cost of $16 billion. This program is supported by an educational grant from Sanofi / Pasteur.   Faculty Disclosure: Dr. Birnbaumer has no relevant financial relationships to disclose.