Protein behaviour can be predicted with simple maths
Oct 10, 2024 ·
5m 23s
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Description
There are more variations of a small protein than there are atoms in the entire universe. Despite the vast possibilities, new research shows predicting mutation effects on protein behaviour is...
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There are more variations of a small protein than there are atoms in the entire universe. Despite the vast possibilities, new research shows predicting mutation effects on protein behaviour is much simpler than previously thought.
Mutations affecting protein stability follow remarkably simple rules, finds new research published in Nature (25 September).
The discovery could simplify how we predict protein behaviour, making it easier and faster to understand the molecular basis of diseases, develop drugs and design new proteins for industrial applications.
Researchers from the Wellcome Sanger Institute and the Centre for Genomic Regulation, Barcelona created thousands of protein variants by introducing different mutations. They tested how these changes affected protein stability and found that despite billions of possible mutation combinations, most follow predictable patterns, meaning complex models are not needed to predict their effects.
show less
Mutations affecting protein stability follow remarkably simple rules, finds new research published in Nature (25 September).
The discovery could simplify how we predict protein behaviour, making it easier and faster to understand the molecular basis of diseases, develop drugs and design new proteins for industrial applications.
Researchers from the Wellcome Sanger Institute and the Centre for Genomic Regulation, Barcelona created thousands of protein variants by introducing different mutations. They tested how these changes affected protein stability and found that despite billions of possible mutation combinations, most follow predictable patterns, meaning complex models are not needed to predict their effects.
Information
| Author | Wellcome Sanger Institute |
| Organization | Wellcome Sanger Institute |
| Website | - |
| Tags |
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