Over the past 24 hours, several key developments have impacted the fantasy football landscape, particularly as teams prepare for Week 12 of the NFL season.

### Bye Week Implications
This week marks the first significant bye week of the season, often referred to as "bye-mageddon." The Cincinnati Bengals, Buffalo Bills, Atlanta Falcons, Jacksonville Jaguars, New York Jets, and New Orleans Saints are all on bye, which means fantasy owners will need to find alternative players to fill their lineups[1][5].

### Running Back Injury Updates
Several running backs are dealing with injuries that could affect their availability for Week 12:

- **Isiah Pacheco**: The Kansas City Chiefs' running back is recovering from a fibula injury and is expected to be healthy enough to play, but his status will depend on his performance in practice this week[3].

- **Tyjae Spears**: The Tennessee Titans' backup running back entered concussion protocol after suffering a concussion in the game against Minnesota. He is likely to miss Week 12, with Julius Chestnut expected to step up as the No. 2 running back behind Tony Pollard[3].

- **Jonathon Brooks**: Brooks, who is set to make his NFL debut, is expected to play for the Carolina Panthers against the Chiefs despite a knee injury. He will operate behind Chuba Hubbard[3].

- **Miles Sanders**: The Panthers' running back is not expected to play in Week 12 due to foot and ankle injuries sustained in Week 10. He is not anticipated to be placed on injured reserve but will miss some time[3].

### Waiver Wire and DFS Considerations
Given the bye week and injury landscape, fantasy owners are advised to pay close attention to waiver wire pickups and DFS strategies. FantasyLabs has shared their top waiver wire pickups for Week 12, which can help owners fill gaps in their rosters[2].

### Practice and Game Preparations
Coaches' comments and practice reports will be crucial in determining the final lineup decisions. For example, Chiefs head coach Andy Reid and Panthers head coach Dave Canales have provided updates on their players' statuses, which will influence fantasy lineup decisions[3].

In summary, the combination of bye weeks and injury updates makes this a critical week for fantasy football owners to stay informed and make strategic decisions to optimize their lineups.